Department of Chemistry & Biochemistry

Mosimann Laboratory

Facility Tour: X-Ray and Computing Facility

This laboratory contains a Bruker-Nonius FR591 single crystal, X-ray diffraction system.

The atoms that make up molecules are so close together we cannot distinguish them using visible light. Consequently, we expose crystals of proteins and nucleic acids to X-rays, which can distinguish individual atoms. In order to generate a complete 3D structure of these molecules, we record hundreds to thousands of X-ray diffraction images of the crystal from all possible angles.

This laboratory also contains multiple Linux workstations loaded with X-ray crystallographic software. The X-ray crystallographic experiment does not directly yield a complete 3D structure. Instead, the X-ray crystallographic data is subjected to a series of computational calculations that can lead to a complete 3D structure at atomic resolution.

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