2010

•  Boyko, A. , Molinier, J., Chatter, W., Laroche, A., Kovalchuk, I. (in press) Acute but not chronic exposure to abiotic stress results in transient reduction of expression levels of the transgene driven by the 35S promoter . New Biotechnology.  

2009

•  Koturbash I, Thomas, J, Kovalchuk O, Kovalchuk, I. (2009) Heat-killed bacteria induce genome instability mouse small intestine, liver and spleen tissues. Cell Cycle , 8(12):1935-9.

•  Boyko A., Matsuoka, A., Kovalchuk, I. (2009) High frequency Agrobacterium tumefaciencs- mediated plant transformations induced by ammonium nitrate. Plant Cell Reports. 28(5):737-57.

•  Greer, M.S ., Eudes, F., Kovalchuk, I. (2009) Effects of Ammonium Nitrate upon Direct Somatic Embryogenesis and Biolistic Transformation of Wheat. New Biotechnology , 26(1-2), 44-52.  

2008

•  Kovalchuk, I . and Kovalchuk, O. (2008) Transgenic Plants as Environmental Biosensors. In Special Issue “Phytosensors: Environmental Sensing with Plants and Plant Cells ”. Sensors , 8, 1539-1558. Review.

•  Boyko A., Kovalchuk, I. (2008) Epigenetics of plant response to stress. Environmental and Molecular Mutagenesis , 49 ( 1 ): 61-72, Review.

2007

•  Kovalchuk, O., V. P. Tryndyak, B. Montgomery, A. Boyko , R. Rodriguez-Juarez, F. Zemp, I. Kovalchuk , A.R. Warbritton, J.R. Latendesse, I. P. Pogribny. (2007) Estrogen-induced rat breast carcinogenesis is characterized by alterations of DNA methylation, histone modifications and aberrant microRNAs expression. Cell Cycle , 6(16), 2010-2018.

•  Kovalchuk, I., Molinier, J., Yao, Y., Kov alchuk, O. (2007) Transcriptome analysis reveals fundamental differences in plant response to acute and chronic exposure to ionizing radiation. Mutation Research , 624(1-2):101-13.

•  Koturbash I, Boyko A , Rodriguez-Juarez R, McDonald R, Tryndyak V, Kovalchuk I , Pogribny I, Kovalchuk O. (2007) Role of epigenetic effectors in maintenance of the long-term persistent bystander effect in spleen in vivo. Carcinogenesis , 28(8):1831-8.

•  Boyko A., Kovalchuk I. ( 2007 ) Genetics and epigenetics of pathogen-induced genome instability. Plant Stress , Review, 1(1), 23-31.

•  Boyko, A. , Kathiria, P., Zemp, F., Yao , Y., Pogribny, I., Kovalchuk, I. ( 2007 ) Transgenerational changes in the genome stability and methylation in pathogen-infected plants. Nucleic Acids Research , 35(5):1714-25. Profiled in “Faculty of 1000” with the factor of “6.0”

2006

•  Boyko , A. Greer, M. and Kovalchuk, I. (2006) Acute exposure to UVB has more pronounced effect on plant genome stability than chronic exposure. Mutation Research , 602, 100-109.

•  Boyko , A., Hudson , D., Bhomkar, P., Kathiria , P. Kovalchuk, I. (2006) Increase of homologous recombination frequency in vascular tissue of Arabidopsis plants exposed to salt stress . Plant and Cell Physiology , 47(6):736-42.

•  Boyko , A., Filkowski , J., Kovalchuk, I. ( 2006 ) Double strand break repair in plants is developmentally regulated. Plant Physiology , 141, 1-10.

•  Boyko , A., Filkowski , J., Hudson, D., Kovalchuk, I. (2006) Homologous recombination in plants is organ specific. Mutation Research , 595, 145-155. 

2005

•  Boyko A., Filkowski J. and Kovalchuk I ( 2005 ) Homologous recombination in plants is temperature and day length dependent. Mutation Research , 572, 73-83.

•  Besplug, J., Filkowski J., Kovalchuk, I. , Kovalchuk, O. ( 2005 ) Sex- and tissue-specific differences in the low-dose radiation-induced oncogenic signaling. International Journal of Radiation Biology , 81, 157-68.

•  Ilnytskyy, Y., Yao , Y. and Kovalchuk, I. ( 2005 ) Double-strand break repair machinery is sensitive to UV radiation. Journal of Molecular Biology , 345, 707-715.

•  Molinier, J., Oakeley, E.J., Niederhauser, O., Kovalchuk, I. Hohn, B. ( 2005 ) Dynamic response of plant genome to ultraviolet radiation and other genotoxic stresses Mutation Research , 571, 235-47.

•  Kovalchuk, I. , Titov, V., Hohn, B. Kovalchuk, O. ( 2005 ) Transcriptome profiling reveals similarities and differences in plant responses to cadmium and lead. Mutation Research , 579, 149-161.

2004

•  Dube, T., Kovalchuk, I. , Hohn, B. and Thomson, JA. ( 2004 ) Agrobacterium tumefaciens Mediated Transformation of Plants by the pTF-FC2 plasmid is Efficient and Strictly Dependent on the MobA Protein. Plant Molecular Biology , 55, 531-539.

•  Filkowski , J., Yeoman , A., Kovalchuk, O. and Kovalchuk, I. ( 2004 ) Systemic plant signal triggers genome instability. Plant J. , 38, 1-11.

•  Kovalchuk, I., Abramov, V., Pogribny, I. and Kovalchuk, O. ( 2004 ) Molecular aspects of plant adaptation to life in the Chernobyl zone. Plant Physiology , 135(1), 357-63 .

•  Filkowski , J., Kovalchuk, O., Kovalchuk, I. ( 2004 ) Genome stability of vtc1 , tt4 and tt5 Arabidopsis thaliana mutants impaired in protection against oxidative stress. Plant J ., 38, 60-69.

•  Ilnytskyy , Y., Boyko , A. and Kovalchuk, I . ( 2004 ) Luciferase-based transgenic recombination assay is more sensitive than b -glucoronidase-based. Mutation Research , 559, 189-97.

•  Kovalchuk O., P onton A. , Filkowski , J and Kovalchuk I. ( 2004 ) Dissimilar genome response to acute and chronic low-dose radiation in male and female mice. Mutation Research, 550, 59-72.

•  Kovalchu k, I. , Pelczar P. and O. Kovalchuk. ( 2004 ) The high frequency of nucleotide misincorporations upon the processing of the double-strand breaks. DNA Repair , 3, 217-223.

•  Besplug J., Filkowski J ., Burke P., Kovalchuk I. and O. Kovalchuk. (2004) Atrazine induces homologous recombination but not point mutation in the transgenic plant-based biomonotoring assay. Arch. Environ. Cont. Toxic . 46 (3), 296-300 .

•  Filkowski , J., Kovalchuk, O. and Kovalchuk, I. ( 2004 ) Dissimilar mutation and recombination rates in Arabidopsis and tobacco. Plant Science , 166, 265-272.

2003

•  Kovalchuk I ., Bojko V., Kovalchuk O., Gloeckler V., Filkowski , J., Heinlein, M. and B. Hohn. ( 2003 ) Pathogen induced systemic plant signal triggers genome instability. Nature, 423, 760-762. Profiled in “Faculty of 1000” with the factor of “9.2”

•  P. Pelczar, V. Glockler and I. Kovalchuk . ( 2003 ) Human and tobacco: organisms with similar genomes size but different genome maintenance strategy. Journal of Molecular Biology , 331, 771-9.

•  Kovalchuk O., Burke P ., Arkhipov A., Kuchma N., James S.J., Kovalchuk I. and Pogribny I (2003) Genome hypermethylation in Chernobyl pine – a mechanisms for radiation adaptation? Mutation Research, 529, 13-20.

•  Filkowski J ., Besplug J., Burke P., Kovalchuk I. and O. Kovalchuk (2003) Recombination- and point mutation-monitoring transgenic plants reveal the genotoxicity of commonly used herbicides 2,4-D and dicamba. Mutation Research , 542(1-2), 23-32 .

•  Kovalchuk, I. , Filkowski , J., Smith, K. and Kovalchuk, O. ( 2003 ) The dualistic nature of radicals: the high-low phenomenon. Plant Cell and Environment, 26, 1531-1539.

•  Kovalchuk, I. Kovalchuk , A. Arkhipov, B. Hohn and Yu. Dubrova. ( 2003 ) Extremely complex pattern of microsatellite mutation in the germline of wheat exposed to the post-Chernobyl radioactive contamination. Mutation Research , 525, 93-101 .

•  Kovalchuk, I. Kovalchuk , P. Telyuk, B. Hohn, V. Titov, L. ( 2003 ) Kovalchuk. Monitoring of the genotoxicity of drinking water from the inhabited areas of Ukraine affected by the Chernobyl accident using plant bioassays. Bulletin of Environmental Contamination and Toxicology , 70, 847-853.

•  Kovalchuk, I . and Kovalchuk O. ( 2003 ) A New Use for Transgenic Plants – Environmental Biomonitors. Biotechnology and Genetic Engineering Reviews , Annual Review , 20, ch. 2.

  2002

•  Li, A., Schurmann, D., Gallego, F., Kovalchuk, I. , B. Tinland ( 2002 ) Repair of damaged DNA by Arabidopsis cell extract. Plant Cell , 14, 263-273.

  2001

  •  Kovalchuk, O., Titov, V., Hohn, B. and I. Kovalchuk ( 2001 ) A sensitive transgenic plant system to detect toxic inorganic compounds in the environment. Nature Biotechnology, 19 , 568-572.

•  Kovalchuk, I . , Kovalchuk, O. and B. Hohn ( 2001 ) Biomonitoring of genotoxicity of environmental factors with transgenic plants. Trends in Plant Scince , Review, 6 , 306-310.

•  Kovalchuk, I . and Kovalchuk O. ( 2001 ) Bioindication with transgenic plants. ISB News Rep. Review , Sep., 1-3.

  2000

  •  Kovalchuk O., Arkhipov A., Dubrova Yu., Hohn B. and Kovalchuk I. Wheat mutation rate after Chernobyl ( 2000 ) Nature 407, 583-584.

•  Kovalchuk I. , Kovalchuk O., Hohn B. Genome-wide variation of the somatic mutation frequency in transgenic plants ( 2000 ) EMBO J ., 19, 4431-4438.

•  Kovalchuk O., Arkhipov A., Barylyak I., Karachov I., Titov, V., Hohn B. and I. Kovalchuk ( 2000 ) Plants experiencing chronic internal exposure to ionizing radiation exhibit higher frequency of homologous recombination than acutely irradiated plants. Mutation Research , 449, p.47-56.

•  Gorbunova, V., Avivi-Ragolski, N., Shalev, G., Kovalchuk, I. , Abbo, S., Hohn, B. and Levy, A. ( 2000 ) A new hyperrecombinagenic mutant of Nicotiana tabacum. Plant J. 24 , 601-611.

•  Kovalchuk , I., Kovalchuk, O., Fritsch, O., Hohn, B. ( 2000 ) Des bio-indicators de pollution radioactive, Biofutur , 205, 48-51.

  1999

  •  Kovalchuk, O.; Kovalchuk, I., Titov, V.; Arkhipov, A. and Hohn, B. ( 1999 ) Radiation hazard caused by the Chernobyl accident in inhabited areas of Ukraine can be monitored by transgenic plants. Mutation Research 446, p.49-55.

•  Hohn B., Kovalchuk I., Kovalchuk O. ( 1999 ) Transgenic plants sense radioactive contamination. Bioworld , 6, p. 13-15.

•  Kovalchuk I. , Kovalchuk O., Hohn B. ( 1999 ) Transgenic plants as bioindicators of environmental pollution. Review. AgBiotechNet, Vol. 1, October, ABN 030.

  1998

•  Kovalchuk I , Kovalchuk O, Arkhipov A, Hohn B. ( 1998 ) Transgenic plants are sensitive bioindicators of nuclear pollution caused by the Chernobyl accident. Nat Biotechnol. 16, 1054-9.

•  Kovalchuk O, Kovalchuk I , Arkhipov A, Telyuk P, Hohn B, Kovalchuk L. ( 1998 ) The Allium cepa chromosome aberration test reliably measures genotoxicity of soils of inhabited areas in the Ukraine contaminated by the Chernobyl accident. Mutat Res. 415(1-2), 47-57.

Contributions by lab members:

Tamminga J, Kathiria P , Koturbash I, Kovalchuk O. (2008) DNA damage-induced upregulation of miR-709 in the germline downregulates BORIS to counteract aberrant DNA hypomethylation. Cell Cycle . 7(23):3731-6.

Ilnytskyy Y, Zemp FJ , Koturbash I, Kovalchuk O. (2008) Altered microRNA expression patterns in irradiated hematopoietic tissues suggest a sex-specific protective mechanism. Biochem Biophys Res Commun. 377(1):41-5.

Tamminga J, Koturbash I, Baker M, Kutanzi K, Kathiria P , Pogribny IP, Sutherland RJ, Kovalchuk O. (2008) Paternal cranial irradiation induces distant bystander DNA damage in the germline and leads to epigenetic alterations in the offspring. Cell Cycle. 2008 May;7(9):1238-45. Epub 2008 Feb 22.

Koturbash I, Zemp FJ , Kutanzi K, Luzhna L, Loree J, Kolb B, Kovalchuk O. Sex-specific microRNAome deregulation in the shielded bystander spleen of cranially exposed mice. Cell Cycle . 2008 Jun 1;7(11):1658-67.

Pogribny I. , Tryndyak V., Boyko A., Rodriguez-Juarez R., Beland F.A. and Kovalchuk O. (2007) Induction of microRNAome deregulation in rat liver by long-term tamoxifen exposure. Mutation Research. 619(1-2):30-7.

Patents:

Kovalchuk I. , Kovalchuk O., Hohn B. Process for monitoring mutations in plants. European Patent Application. European Patent EP1176211.

Kovalchuk, I., Boyko, A . (2006) “Composition and method for enhancing plant transformation and homologous recombination ” United States Patent 20080052790 . WO/2008/022442

Kovalchuk, I. , Bhomkar, P. Monocots transformation via DNA/protein complexes (pending; Disclosure agreement KOI 05-002 )

Kovalchuk, I. , Maheshwari, P. Method of transforming plants. (pending).

Kovalchuk, I. , Boyko, A. Composition and method for modulating plant transformation. EFS ID 5036459