Congratulation to all participants of
the symposium for giving great presentations, with special congratulations to
the winners:
1st place: Elani Bykowski
2nd place: Janet Poplawski
3rd place: Jessica Kuntz
Honourable mention: Clarissa Beke
Abstracts
Development
1.
Building Brains and Futures: Improving Executive Function and Emergent Literacy
in Children by Developing Adult Ability
Niehaus, C., Harker, A., Raza, S., Carvalho, A., Mendoza, M., Rathwell,
B., Halliwell, C., Piquette,
N., Gibb, R.
Executive function (EF) and
emergent literacy (EL) skills are crucial to children’s development and future
life success. In order to support these
skills through parental and early childhood educators (ECE), a curriculum was
developed to enhance EF and EL preschool learning in children aged 2-6 and an
early childhood program was implemented at two sites, running for a duration of
10 months. Quantitative and qualitative data was collected from the ECE,
parents and children as a means to look at developmental growth. Preliminary
reports suggest that this program helped improve understanding of the
importance of EF and EL skills as well as encouraging the development of these
skills in the children participating.
2.
Ultrasonic vocalizations as a tool to asses behavioral and developmental
abnormalities: Paternal preconception alcohol exposure
Lindsay Amatto,
Allonna Harker, Rachel Dombowsky,
Fangfang Li, Bryan Kolb, Robbin
Gibb
Rodents
emit ultrasonic vocalizations (USVs) as a means of communication and can be
used to elucidate their affective states and environments. USVs follow a
typical developmental profile throughout rodents’ lifespan, making them a
beneficial neurodevelopmental property to study. It has been observed that
exposing specific toxicants to parents prior to conception has caused
behavioral and developmental abnormalities in offspring. In this experiment,
male rodents were administered alcohol for an entire spermatogenic
cycle and then immediately mated. After breeding, these males spent the next spermatogenic cycle without alcohol and were mated again to
examine the relevance of temporally varied alcohol exposure and conception on
vocalizations. Multiple parameters were then used to analyze the vocalizations
of all offspring.
Disease models, Stress, and Addiction
3. Risking all the cheese: do unpredictable rewards lead to addictive behaviour in rats?
Danika Dorchak, Catherine Laskowski,
David Euston
Random-ratio (RR) schedules of reinforcement, like those used in slot
machines, provide unpredictable rewards versus fixed-ratio (FR) schedules,
where the rewards are expected. RR schedules are considered to be more
“addictive” than FR schedules, but is this why people develop gambling
addiction? We examined two groups of rats that received food pellets under
different reinforcement schedules over a prolonged period and then measured for
addiction-like behaviour. If the RR schedule is
inherently addictive, then we expect to see the RR group showing more signs of
addiction. While the RR group consistently finished faster than the FR group,
they did not show signs of addiction.
4. Early
Postnatal Stress Accelerates the Functional Development of the Visual System
Janet Poplawski, Shrianne
Ryan, Amanda Weiler, Gerlinde A.S. Metz
Early
life stress (ES) has been associated with adverse health outcomes in adulthood.
Studies have linked ES to increased risk of schizophrenia, depression, and behavioural disturbances in children. However, little is
known about the mechanisms underlying these changes. In this study the
functional development of the visual system, the premier model of developmental
brain plasticity, was assessed in mice exposed to ES. We found that ES induced
accelerated development of the visual system and these changes were associated
with maladaptive behaviours throughout life. This
research provides insights into the impact of experience on early brain
development.
5. Chronic adolescent exposure to
THC: analysis of anxiety-related behaviour in rodents
using the elevated plus maze and risk-assessment measures
Marisa
Lelekach, Jill Sabourin,
Serena Jenkins, Rachel Dombowsky, Allonna
Harker, Diana Dow-Edwards, Brian Kolb, Robbin Gibb
Marijuana
is one of the most widely used drugs among adolescence; a time when
over-activation of the endocannabinoid system may cause neurobiological changes
that influence the function and behaviour of the
adult brain later in life. The current study focuses on the effect of chronic
adolescent exposure to THC, the main psychoactive component of marijuana, on
anxiety-related behaviour using the elevated-plus
maze. Risk-assessment measures were also evaluated, as an additional measure of
this behaviour.
6. Long lasting Jet lag: Postnatal
shipment stress and its effects on exploratory behaviour
Shawn
Whale, Janet Poplawski, Gerlinde A.S. Metz
Stress
can act adversely on individuals. Previous studies found negative phenotypical
responses to shipment stress, but less has been researched on behavioural effects. Here, we exposed young mice to
shipment stress and examined their anxiety-like behaviours
during adolescence. The stressed mice traversed less of the center of an open
field test and moved through less space than controls. These results suggest
that shipment stress decreases exploratory behaviour
and may induce anxiety-like behaviours in mice. These
findings have important implications for standard procedures involving
laboratory animals.
Sensory and Motor Systems
7. Vocalization and Behavioural Coding
Carmalita Robertson, Candace
Burke, Sergio Pellis
Rats
produce ultrasonic vocalizations that emit differently depending on the
animal’s age, environmental condition and affective state. Research at the CCBN
focused on whether rats made certain vocalizations when expressing certain behaviour. The theory is that ultrasonic communication in
rats is used as a way to communicate affective state and organize social
communication. Findings show 50kHz calls linked with active behaviours
and 22kHz calls correlated to anxiety. Mapping out
ultrasonic vocalizations associated behaviours gives
insight to the rat’s emotional brain. When testing drugs on rats this can
suggest effects of the drug onto the rat and explain underlying psychiatric
disorders.
8. Ventrally mediated grasps: Is
the left hemisphere grasp-to-eat advantage limited to the dorsal stream?
Clarissa
Beke, Jason Flindall,
Claudia Gonzalez
Results
from studies in the Brain in Action lab have shown that the left hemisphere is
specialized for grasp-to-eat actions: The right hand is more precise at
grasping food with the intention to eat rather than to place. Those results
however come from actions executed under visual guidance (dorsal visual
stream). The present study investigates whether the right hand advantage for
grasp-to-eat actions remains present in delayed, i.e. grasps without vision,
conditions (ventral visual stream).
9. Grow with the flow: visual
fixations and saccades in dynamic sports environments
Elani Bykowski,
Jon Doan
Executing
skillful movement requires rapid perception and interpretation of complex
visual information. This same information provides provoking cues for people
with some neuropathologies, including Parkinson
disease. We used vision tracking to determine which visual cues attracted
attention. While participants observed still pictures and moving scenes of
biking, walking, and ice skating on a stimulus monitor, a stationary eye
tracker measured the fixations and saccades of participants’ eyes. Differences
in fixation and saccade were also observed for people living with PD.
10. Dissociation
of the Reach and Grasp in mice: The Evolutionary Predecessor of the Dual Visuomotor Channel theory?
Jessica
Kuntz, Ian Whishaw, Majid Mohajerani
The Dual Visuomotor Channel theory proposes that primate prehension consists of two movements, a Reach and a Grasp. Rodents make similar skilled movements but it is
unknown whether they reflect dual channel organization. This study used
head-fixed mice in a reaching apparatus to dissociate the two movement
components. The Mice used a reach to locate the food and then used a grasp for
object purchase demonstrating that the Reach and Grasp are separate. The
dissociation supports Dual Channel theory and further suggests that the
channels were co-opted for the visual control of reaching in primate.
Learning and
Memory
11. The hippocampus is
not necessary for cued location or discriminative cue memory in a novel
two-platform task in rats.
Deryn LeDuke,
Justin Lee, Robert Sutherland
A
novel visible two-platform water task (TPWT) was designed to investigate the
role of the hippocampus in memory for cue locations and visible cues, and how
these types of memory interact. Spatial and visible cue memory acquisition and
retrieval were tested in hippocampus-lesioned and sham control Long-Evans rats.
Results show that memories for locations and visible cues guide behavior in
hippocampal rats, and that spatial navigation strategies overshadow the
acquisition and utilization of visible cue memory in controls. These findings
contribute to the current body of work that investigates how multiple types of
memory to control behavior.
12. Ventral Hippocampus Learning in
The Mammalian Brain: An investigation of inhibitory associations on a visual
discrimination task and early goal-oriented search strategies on a spatial
navigation task
Emily
Stuart, Brianna Carrels, Nhung Hong, Robert McDonald
The
theory of multiple memory systems proposes that there are separate memory
systems within the mammalian brain that process information and influence
learning and memory independently. Such systems also influence behavior by
interacting with one another either cooperatively or competitively. Although
the hippocampus is widely studied within learning and memory literature, the
ventral hippocampus is often overlooked as a separate structure that has a
distinct function from the dorsal segment within learning and memory processes.
For the present study, we further investigated the role of the ventral
hippocampus in acquiring a visual discrimination task and a spatial navigation
task.
13. Disrupted Circadian Rhythms
Impair Spacial Learning and Memory in Fisher Brown
Norway Rats Three Months after Initial Disruption
Moore
K., Deibel S., Hong N., Mysyk
T., McDonald R.
Endogenous
circadian rhythms are generated by the brain’s master clock, the
suprachiasmatic nucleus. Healthy circadian rhythms synchronize to the
environmental day-night cycle. Disrupted circadian rhythms have been linked to
memory impairment by previous research. Here we investigated the influence of
disrupted circadian rhythms on spacial learning and
memory in fisher brown Norway rats. The environmental day-night cycle was
manipulated to disrupt the rodents’ endogenous circadian rhythms. Spacial learning and memory was evaluated during and after
circadian rhythm disruption. Animals with disrupted circadian rhythms performed
well in the standard water maze, but performed poorly in massed training water
maze months later.
New Methods and Technologies
14. Investigation of Dual Channel
Theory Using DREADD
Behroo Mirzaagha,
Majid Mohajerani
The
Dual Channel Theory of reaching proposes that reaching consist of two
movements: the Reach, which advances the hand to the target and the Grasp,
which shapes the hand for target purchase. This theory proposes that the two
channels are comprised of nodes and edges that connect somatosensory to motor
cortex, and that inactivation of the channels at any point should produce
equivalent impairment in Reach and Grasp. This hypothesis is examined using
inhibitory DREADD that temporarily inactivates the function of different cell
types. The findings may provide insights to how sensory and motor cortices
interact to produce movement.
15. Ringematics: Developing biomechanical measures for
a novel neurotherapeutic exercise
Mariko
Boulet, Jon Doan
Skating
and stickhandling are functionally and physically available to many Canadians
living with Parkinson’s disease. Previous research from our lab has shown that
these activities led to improvement on clinical and functional tests of upper
extremity motor performance for Parkinson’s patients. Ringhandling
may be even more comprehensive than stickhandling; however, very little
research has been completed on ringette skills thus far. To date, we have
tested young adult ringette experts on on-ice ringhandling
drills and we hope to use the data collected as the initial stages of
introducing ringhandling as a neurotherapeutic
exercise method for those living with Parkinson’s disease.
16.
How robots localize sound: An exploration of high frequencies used in sound
localization
Marko
Ilievski, Matthew Tata
Humans are able to
localize sounds of any amplitude in any acoustical environment. However, this
task has proven to be difficult in the domain of humanoid robots as the
acoustics of the environment and external noises can create large uncertainties
when localizing. With the use of the iCub humanoid
robot, this presentation will demonstrate how uncertain information within the
high frequency domain can be compiled over successive head rotations to
establish an accurate audio map.